Relation thyroid hormones with Lipid Profile and Lipid Ratio Overt Hypothyroidism Patients in Misurata

Authors

  • Fatma Mukhtar Elabid Midecal laboratory tecnation in center Misurata midecal
  • Adel Mohammed Mlitan a member at faculty of science Misurata universit
  • Huda Shaban Elgubbi a member at faculty of science Misurata universit
  • Amal Abdelkarim Swayeb a member at faculty of Environmental and Natural recourse of Misurata universit

Abstract

Overt hypothyroidism (OH) has been found to be a pathogenic relationship with dyslipidaemia, that is leading to risk CVD. The current study aimed to investigating the Relationship, thyroid hormone with lipid profile and lipid ratios in overt hypothyroidism patients in Misurata.                                                

The data for the present case - control study was carried out on 115 (83 patients diagnosed OH and 32 control), aged (20 to above 50 years old), who attended the outpatient and inpatient diabetic and endocrine center in Misrata, from 27th December, 2017 to 21th March 2018. Their blood was collected for determination of Free Tri-iodothyronine (FT3), Free Tetra- iodothroxine (FT4) and Thyroid Stimulating Hormone (TSH) by using) Elecsys 2010 autoanalyser(, whereas the lipid profile Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) using )I Lab 300 plus( Clinical Chemistry System, and lipid ratios (TG / HDL, TC / HDL and LDL / HDL),Very Low  Density Lipoprotein (VLDL) (Formulas Fried Ewald). The association was analyzed using SPSS version 19.0 and was expressed as Person correlation coefficient, with (P ≤ 0.05).

References

Abd AL- Fatah, H. S. (2008). Effect of thyroid gland dysfunction on serum leptin and lipid profile in women. (Master dissertation, University of Baghdad), 1-97.

Adlat, S. A., Shamsan, B., & Al-Eryani, E. (2016). Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study. Yemeni Journal for Medical Sciences, 10, 6-14.

Amer, H. R., & Haridas, N. (2017). Correlation between Thyroid-Stimulating Hormone and Lipid Profile in female patients of clinical and subclinical hypothyroidism. PARIPEX- Indian Journal of Research, 6(9), 1-3.

Dipankar, S. P., Mali, B. Y., Borade, N. G., & Patwardhan, M. H. (2012). Estimation of lipid profile, body fat percentage, body mass index, waist to hip ratio in patients with hypothyroidism and hyperthyroidism. J Phys Pharm Adv, 2(9), 330-336.

Duntas, L., H. (2002). Thyroid disease and lipids. Journal of the American Thyroid, 12(4), 287-293.

Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma. without use of the preparative ultracentrifuge. Journal of Clinical chemistry, 18(6), 499-502.‏

Hammes, S. R., & Davis, P. J. (2015). Overlapping nongenomic and genomic actions of thyroid hormone and steroids. Journal of Best practice & research Clinical endocrinology & metabolism, 29(4), 581-593.

Huang, F., Wu, L., Qiu, Y., Bu, K., Huang, H., & Li, B. (2019). The role of free triiodothyronine in high-density lipoprotein cholesterol metabolism. Medicine, 98(36), 1-5.

Kavitha, M. M., Chandrashekharayya, S. H., Sangappa, V., Kashinakunti, M. R., & Gurupadappa, K. (2016). A study to assess the relation between severity of hypothyroidism and Lipid parameters. International Journal of Clinical Biochemistry and Research, 3(1), ISSN 2394-6369, 23-27.

Khalife, H., Khalife, H., Farhat, S., Khalife, H., & Abdel-Sater, F. (2017). A retrospective Study in Lebanon. Thyroid – Stimulating hormone and its Possible association with serum lipids. World Journal of pharmacy and pharmaceutical Sciences, 6(11), 81-92.

Khan, M. A. H., Majumder, I., Hoque, M., Fariduddin, M., Mollah, F. H., & Arslan, M. I. (2013). Lipid profile in hypothyroid patients: a cross sectional study. Journal of Medicine today, 25(1), 21-24.

Mahajan, R. D., & Singh, R. (2011). Thyroid dysfunction and total cholesterol-experience in a tertiary care hospital. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2(2), 268-273.

Malik, A., Zaman, A., Izhar, K., & Iqbal, Y. (2018). Correlation of Thyroid Stimulating Hormone with Homocysteine and Lipid Profile in Hypothyroidism. Journal of Liaquat University of Medical & Health Sciences, 17(03), 147-151.

Masullo, L. F., Magalhaes, R. A., Lemes, R. P. G., de Almeida Filho, T. P., de Castro, M. F., Maia Filho, P. A., Cunha, T. O. V., Quidute, A. R. P., Fontenele, E. G. P., Sun, G., & Martins, M. R. A. (2018). Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism. Journal of frontiers in Endocrinology, 9(655), 1-5.

Saini, V., Yadav, M. A., Arora, S., Singh, R., & Bhattacharjee, J. (2012). Association between different degrees of hypothyroidism and serum lipids. Internet Journal of Medical Update-EJOURNAL, 7(2), 3-8.

Sangeeta, N., Singh, Y. A., Devi, O. P., Singh, R. R., Chubalemla, L., Abhishek, D., Basar, G., Ibrahunlang, R., Devi, N. O., & Singh, M. A. (2016). Lipid Profile in Thyroid Dysfunction Patients. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 15(12), 39-43.

Shashi, A., & Sharma, N. (2012). Lipid profile abnormalities in hypothyroidism. International Journal of Science and Nature, 3(2), 354-60.

Yousif, B. M. (2001). Determination of some Trace Elements in Serum of Hyperthyroidism and Hypothyroidism patients. (Doctoral dissertation, University of Khartoum), 1-95.

Downloads

Published

2024-01-01

How to Cite

Elabid, F. M., Mlitan, A. M., Elgubbi, H. S., & Swayeb, A. A. (2024). Relation thyroid hormones with Lipid Profile and Lipid Ratio Overt Hypothyroidism Patients in Misurata. Journal of Academic Research, 28, 89–83. Retrieved from https://lam-journal.ly/index.php/jar/article/view/481

Issue

Section

Article