Comparison of the prevalence and trends of Hepatitis B among blood donors in Tripoli, Misurata and Zleetin cities: Two years before and after Libyan incidences
Abstract
Hepatitis B virus is considered as a serious public health problem. Infection of this virus might lead to more serious clinical consequences. This study was conducted to estimate and compare the prevalence and trend of HBV infection among blood donors of three cities in Libya, Tripoli, Misurata and Zleetin and to explore the effect of Libyan incidences on the trend of the infection. A retrospective study was carried out on 72146 nationwide voluntary blood donors in four blood banks, covering the three cities over a period of four years (2009-2013), where serologic screening assay for HBsAg was performed. Findings showed statistically significant differences (P<0.05) in the prevalence of the virus among the cities over the period mentioned. Results also indicated an increasing trend in the overall prevalence of the virus in Tripoli and decreasing trend in Misurata and Zleetin (P >0.05) after Libyan incidences with no statistically significant difference. Sensitive tests such as nucleic acid amplification are recommended for more accurate results
References
- Kalepoto GN, Bhally HS, Khaliq G, et al. Epidemiology of blood-borne viruses. A study of health blood donors in southern Pakistan. J. Pak. Med. Assoc.1996; 27: 703-6.
- Rehermann B and Nascimbeni M. Immunology of Hepatitis B virus and Hepatitis C virus infection. Nature Publishing Group. 2005; 5: 215-229.
- Ishak KG. Pathologic features of Chronic Hepatitis. Am. J. Clin. Path. 2000; 11: 40-
- Kumar et al. Robbin and Cotran pathologic basis of disease, Elswvier 7th ed. 2005:
-898.
- Nazar H, Nadia N, Shazia N, et al. Prevalence of hepatitis B and hepatitis C in blood donors in Karachi. Biomedica. 2008; 24: 116-117.
- Kaur P and Basu S. Transfusion-transmitted infections: existing and emerging
pathogens. J Postgrad Med. 2005; 51 (2):146-51.
- Bihl F, Castelli D, Marincola F, et al. Transfusion transmitted infections. J Transl
Med. 2007; 5:25.
- Salawu L, Bolarinwa RA, Adegunloye AB, et al. HBsAg, anti-HCV, anti-HIV
and VDRL in blood donors: Prevalence and trends in the last three and a half years in a
tertiary health care facility in Ile-Ife, Nigeria. International Journal of Medicine and
Medical Sciences. 2010; 2 (11): 335-34.
- Hwang EW and Cheung R. Global Epidemiology of Hepatitis B Virus (HBV)
Infection. N A J Med Sci. 2011; 4 (1): 7-13.
- McMahon BJ, Alward WL, Hall DB, et al. Acute hepatitis B virus infection: relation
of age to the clinical expression of disease and subsequent development of the carrier
state. J Infect Dis. 1985; 151(4): 599-603.
- Ott JJ, Stevens GA, Groeger J, et al. Global epidemiology of hepatitis B virus
infection: New estimates of age-specific HBsAg seroprevalence and endemicity.
Vaccine. 2012; 30: 2212– 2219.
- Kerubo G, Khamadi S, Okoth V, et al. Hepatitis B, Hepatitis C and HIV-1
Coinfection in Two Informal Urban Settlements in Nairobi, Kenya. PLoS ONE. 2015;
(6): e0129247.
- Goldstein S T, Zhou F, Hadler S C, et al. A mathematical model to estimate global
hepatitis B disease burden and vaccination impact. International Journal of
Epidemiology. 2005; 34: 1329–1339.
- Sheriff HA. Prevalence of Hepatitis B and C Among Normal Individuals in
Tripoli/Libya. AJPS. 2010; 8 (2): 104-109.
- Abed Al-Gani F. Prevalence of HBV, HCV and HIV-1, 2 infections among blood
donors in Prince Rashed Ben Al-Hassan Hospital in North Region of Jordan. Int J
Biol Med Res. 2011; 2 (4): 912-916.
- Gurol E, Saban C, Oral O, et al. Trends in hepatitis B and hepatitis C virus among
blood donors over 16 years in Turkey. Eur J Epidemiol. 2006; 21 (4): 299-305.
- Lee HH and Allain JP. Improving blood safety in resource-poor settings. Vox
Sanguinis. 2004; 87 (2):176-179.
- Hwang EW and Cheung R. Global Epidemiology of Hepatitis B Virus (HBV)
Infection. N A J Med Sci. 2011; 4 (1): 7-13.
- Singh K, Bhat S and Shastry S. Trend in seroprevalence of Hepatitis B virus infection
among blood donors of coastal Karnataka, India. J Infect Dev Ctries. 2009; 3(5): 376-
- Makroo RN, Hegde V, Chowdhry M, et al. seroprevalence of infectious markers &
their trends in blood donors in a hospital based blood bank in north india. Indian J
Med Res. 2015; 142: 317-322.
- Abou MA, Eltahir YM and Ali AS. Seroprevalence of Hepatitis B virus and Hepatitis
C virus among blood donors in Nyala, South Dar Fur, Sudan. Virology Journal. 2009;
:146.
- Mohammed Y and Bekele A. Seroprevalence of transfusion transmitted infection
among blood donors at Jijiga blood bank, Eastern Ethiopia: retrospective 4 years
study. BMC Res Notes. 2016; 9:129.
- Gust ID. Epidemiology of hepatitis B infection in the Western Pacific and South East
Asia. Gut. 1996; 38(2):18–23.
- Al-Mekhaizeem KA, Miriello M and Sherker AH. The frequency and significance of
isolated hepatitis B core antibody and the suggested management of patients. CMAJ.
; 165(8): 1063-1064.
- Hoofnagle JH, Seefe LB, Bales ZB, et al. Type B hepatitis after transfusion with
blood containing antibody to hepatitis B core antigen. N Engl J Med . 1978; 298:
- 1383.
- Tegtmeir G, Henderson S, McNamara A, et al. Contribution of anti-HBc screening to
blood safety at a regional blood center in the United States. Transfusion. 1997; 37
(9S): 110s [abstract439].
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