The Relationship between D-dimer test and COVID-19

Randa Mohamed Elsalhi; Fatma Milad Alzin; Mustafa Mohammed Drah; Amna Mustafa Bayo

المؤلفون

Randa Mohamed Elsalhi Department of Medical laboratories sciences, Misurata University, Misurata, Libya. ,
Fatma Milad Alzin Department of Medical laboratories sciences, Misurata University, Misurata, Libya.
Mustafa Mohammed Drah Department of Zoology, Misurata University, Misurata, Libya.
Amna Mustafa Bayo Department of Zoology, Misurata University, Misurata, Libya

الكلمات المفتاحية:

Prevalence COVID-19، dimer test، Integra system، Thrombosis

الملخص

Background: COVID-19 is common disease in the world, and it has caused many complications to humans, D-dimers have been shown to be of prognostic value in various diseases, including cardiovascular disease and cancer, and D-dimer is currently the best available marker for COVID-19 associated hemostatic abnormalities. The objective of this study was found the relationship between D-dimer and COVID-19 in the patients.

Methods: In this study 3913 samples were collected from patient with COVID-19, from January 2020 to April 2021, A D-dimer test was conducted at the Misurata Central Laboratory, the Most of the cases that have a high D-dimer protein result have serious complications such as thrombosis and pulmonary embolisms.

The normal range of D-dimer was taken as <0.5 mg/dl as per our laboratory standards. A convenience sampling method was used.

Results: Out of the total 3913 cases of COVID-19 included in this study, 1551 (39.64%) patients had elevated D-dimer by using Integra 400 plus system (P value <0.05) by SPSS.

المراجع

(1) Prompetchara, E., Ketloy, C., & Palaga, T. (2020). Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pacific journal of allergy and immunology, 38(1), 1-9.‏

(2) Guo, Y. R., Cao, Q. D., Hong, Z. S., Tan, Y. Y., Chen, S. D., Jin, H. J., ... and Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Military Medical Research, 7(1), 1-10

(3) Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., ... and Feng, Z. (2020). Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. New England journal of medicine.‏

(4) Adam, S. S., Key, N. S., and Greenberg, C. S. (2009). D-dimer antigen: current concepts and future prospects. Blood, The Journal of the American Society of Hematology, 113(13), 2878-2887.‏

(5) Khatri, P., Agrawal, K. K., Sharma, D., Chhetri, P., Neupane, A., Piriyani, R. M., ... & Bharali, S. (2021). Prevalence of Elevated D-dimer Levels in Confirmed COVID-19 Cases in Intensive Care Unit of a Tertiary Care Centre of Western Nepal. Journal of the Nepal Medical Association, 59(235).‏

(6) Tasić, N., Paixão, T. R., and Gonçalves, L. M. (2020). Biosensing of D-dimer, making the transition from the central hospital laboratory to bedside determination. Talanta, 207, 120270.‏

(7) Adam, S. S., Key, N. S., and Greenberg, C. S. (2009). D-dimer antigen: current concepts and future prospects. Blood, The Journal of the American Society of Hematology, 113(13), 2878-2887.‏

(8) Song, X., Ji, J., Reva, B., Joshi, H., Calinawan, A. P., Mazumdar, M., ... & Veluswamy, R. R. (2021). Post-anticoagulant D-dimer is a highly prognostic biomarker of COVID-19 mortality. ERJ Open Research.‏

(9) Velavan, T. P., & Meyer, C. G. (2020). Mild versus severe COVID-19: laboratory markers. International Journal of Infectious Diseases, 95, 304-307.‏