دراسة مقارنة معدل نقص فيتامين د وبعض التحاليل ذات العلاقة في مناطق شمال وجنوب ليبيا
Keywords:
نقص فيتامين د, ليبيا, الكالسيوم, الفوسفور, الماغنسيومAbstract
يعد انتشار نقص فيتامين د وباءً عالمياً ومصدر قلق للصحة العامة، وتعتبر بعض المجموعات السكانية أكثر عرضة لنقص فيتامين د من عامة السكان، وتشمل هذه المجموعات الرضع والأطفال والنساء الحوامل وكذلك النساء في سن الإنجاب، وذلك بسبب زيادة التمثيل الغذائي لديهم والحاجة الغذائية لفيتامين د، ونظراً لكون نقص فيتامين د مشكلة صحية عالمية وشائعة ومرتبطة بالعديد من الأمراض المعدية وغير المعدية، لذلك هدفت هذه الدراسة لمقارنة نقص فيتامين د وبعض التحاليل ذات العلاقة به بين مناطق شمال ليبيا وجنوبها.
المواد والطرائق: اشتملت الدراسة على 300 عينة منها 150 عينة من مناطق الشمال الليبي و150 عينة من مناطق الجنوب الليبي، (75عينة منها رجال، و75 عينة نساء)، جمعت عينات الدم وتم قياس تركيز فيتامين د، والكالسيوم، والفوسفور والماغنسيوم لجميع عينات الدراسة، وتم تحليل البيانات احصائيا باستخدام برنامج SPSS.
النتائج: أظهرت النتائج أن معدل نقص فيتامين د في مناطق جنوب ليبيا كان (42.66%) وهو أعلى من معدل النقص في مناطق الشمال (29.66%)، كما أظهرت الدراسة أن النساء أكثر عرضة من الرجال لنقص فيتامين د في كل مناطق الدراسة، وأن التعرض لأشعة الشمس واستخدام واقيات الشمس، ونوع النظام الغذائي، والتدخين، والسمنة، كلها عوامل تؤثر على مستوى فيتامين د في المصل.
الخلاصة: إن الاختلافات البيئية، والعرقية، ونمط الحياة، والموقع الجغرافي، ونوع النظام الغذائي عوامل أثرت على اختلاف نسب مستوى فيتامين د بين مناطق الدراسة.
References
Dahiya, K., Pal, S., &Dhankhar, R. (2020). Vitamin D in Physiological and Pathological Conditions.
Sizar, O., Khare, S., Goyal, A., Bansal, P., &Givler, A. (2021). Vitamin D deficiency. StatPearls [Internet].
Mendes, M. M., Charlton, K., Thakur, S., Ribeiro, H., & Lanham-New, S. A. (2020). Future perspectives in addressing the global issue of vitamin D deficiency. Proceedings of the Nutrition Society, 79(2), 246-251.
Cashman, K. D. (2022). 100 YEARS OF VITAMIN D: Global differences in vitamin D status and dietary intake: a review of the data. Endocrine Connections, 11(1).
Renke, G., Starling-Soares, B., Baesso, T., Petronio, R., Aguiar, D., &Paes, R. (2023). Effects of vitamin D on cardiovascular risk and oxidative stress. Nutrients, 15(3), 769.
Pludowski, P., Takacs, I., Boyanov, M., Belaya, Z., Diaconu, C. C., Mokhort, T., ... &Pilz, S. (2022). Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a central and eastern European expert consensus statement. Nutrients, 14(7), 1483.
Pilz, S., Zittermann, A., Trummer, C., Theiler-Schwetz, V., Lerchbaum, E., Keppel, M. H., ... & Pandis, M. (2019). Vitamin D testing and treatment: a narrative review of current evidence. Endocrine connections, 8(2), R27-R43.
Parna, S Muthathal, B Nogknrih. (2021). Journal of International Medicine/ Volume289, Issue/P, 97-115.
Sorrenti, V., Buriani, A., Davinelli, S., Scapagnini, G., &Fortinguerra, S. (2023). Vitamin D Physiology, Deficiency, Genetic Influence, and the Effects of Daily vs. Bolus Doses of Vitamin D on Overall Health: A Clinical Approach. Nutraceuticals, 3(3), 403-420.
Zappulo, F., Cappuccilli, M., Cingolani, A., Scrivo, A., Chiocchini, A. L. C., Nunzio, M. D., ... & La Manna, G. (2022). Vitamin D and the Kidney: Two players, one console. International Journal of Molecular Sciences, 23(16), 9135.
Pereira, M., Dantas Damascena, A., Galvão Azevedo, L. M., de Almeida Oliveira, T., & da Mota Santana, J. (2022). Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Critical reviews in food science and nutrition, 62(5), 1308-1316.
Capelli, I., Cianciolo, G., Gasperoni, L., Galassi, A., Ciceri, P., &Cozzolino, M. (2020). Nutritional vitamin D in CKD: Should we measure? Should we treat?. ClinicaChimicaActa, 501, 186-197.
Jamali, N., Sorenson, C. M., &Sheibani, N. (2018). Vitamin D and regulation of vascular cell function. American Journal of Physiology-Heart and Circulatory.
Bhattarai, H. K., Shrestha, S., Rokka, K., & Shakya, R. (2020). Vitamin D, calcium, parathyroid hormone, and sex steroids in bone health and effects of aging. Journal of osteoporosis, 2020 (1), 9324505.
Vázquez-Lorente, H., Herrera-Quintana, L., Molina-López, J., Gamarra-Morales, Y., López-González, B., Miralles-Adell, C., &Planells, E. (2020). Response of vitamin D after magnesium intervention in a postmenopausal population from the province of Granada, Spain. Nutrients, 12(8), 2283.
Dominguez, L. J., Farruggia, M., Veronese, N., &Barbagallo, M. (2021). Vitamin D sources, metabolism, and deficiency: available compounds and guidelines for its treatment. Metabolites, 11(4), 255.
Shifrin, A. (2020). Brief overview of calcium, vitamin D, parathyroid hormone metabolism, and calcium-sensing receptor function. Advances in Treatment and Management in Surgical Endocrinology, 63-70.
Bilezikian, J. P., Silverberg, S. J., Bandeira, F., Cetani, F., Chandran, M., Cusano, N. E., ... & Potts, J. T. (2020). Management of primary hyperparathyroidism. Journal of Bone and Mineral Research, 37(11), 2391-2403.
Khamis, E., Hemdan, G., & Dabou, E. (2020). Influence of Vitamin D Level on Self-Perceived Fatigue, Body Mass Index and Health Related Quality of Life among Female Nurses in Two Governorates. Egyptian Journal of Nursing and Health Sciences, 1(Second Issue), 18-47.
Kheiri, B., Abdalla, A., Osman, M., Ahmed, S., Hassan, M., &Bachuwa, G. (2018). Vitamin D deficiency and risk of cardiovascular diseases: a narrative review. Clinical hypertension, 24(1), 1-9.
Płudowski, P., Kos-Kudła, B., Walczak, M., Fal, A., Zozulińska-Ziółkiewicz, D., Sieroszewski, P., ... &Misiorowski, W. (2023). Guidelines for preventing and treating vitamin D deficiency: a 2023 update in Poland. Nutrients, 15(3), 695.
Islam, M. Z., Bhuiyan, N. H., Akhtaruzzaman, M., Allardt, C. L., &Fogelholm, M. (2022). Vitamin D deficiency in Bangladesh: A review of prevalence, causes and recommendations for mitigation. Asia Pacific journal of clinical nutrition, 31(2), 167-180.
Ateeg, S. A. I., &Atbeeqah, K. M. A. (2023). Measurement Of vitamin D Deficiency and Calcium Level in Western Libya, 8(4), 183-191.
Cashman, K. D. (2020). Vitamin D deficiency: defining, prevalence, causes, and strategies of addressing. Calcified tissue international, 106(1), 14-29.
Radonsky, V., Lazaretti-Castro, M., Chiamolera, M. I., Biscolla, R. P. M., Lima, J. V., Vieira, J. G. H., ... &Cavichio, M. W. E. (2024). Alert for the high prevalence of vitamin D deficiency in adolescents in a large Brazilian sample. Jornal de Pediatria, 100(4), 360-366.
Grant, W. B., Bhattoa, H. P., &Pludowski, P. (2024). Determinants of vitamin D levels from sun exposure: a global perspective. In Feldman and Pike's Vitamin D (pp. 97-113). Academic Press.
Mendes, M. M., Araújo, M. M., Botelho, P. B., & de Carvalho, K. M. B. (2024). Seasonal and sex-related variation in vitamin D status and its association with other biochemical markers in young individuals: A cross-sectional study. Plos one, 19(3), e0298862.
Bahrami, A., Sadeghnia, H. R., Tabatabaeizadeh, S. A., Bahrami‐Taghanaki, H., Behboodi, N., Esmaeili, H., ... &Avan, A. (2018). Genetic and epigenetic factors influencing vitamin D status. Journal of cellular physiology, 233(5), 4033-4043.
Butt, T. A., Yasmeen, F. A. R. Z. A. N. A., Alavi, N. U. S. R. A. T., &Mumtaz, A. (2014). Comparison of Vitamin D levels between urban and rural college students. Pak J Med Health Sci, 8(4), 912-5.
Choi, J. H., Lee, B., Lee, J. Y., Kim, C. H., Park, B., Kim, D. Y., ... & Park, D. Y. (2020). Relationship between sleep duration, sun exposure, and serum 25-hydroxyvitamin D status: a cross-sectional study. Scientific reports, 10(1), 4168.
Alswat, K. A. (2017). Gender disparities in osteoporosis. Journal of clinical medicine research, 9(5), 382.
Beto, J. A. (2015). The role of calcium in human aging. Clinical nutrition research, 4(1), 1-8.
Yoo, K. D., Kang, S., Choi, Y., Yang, S. H., Heo, N. J., Chin, H. J., ... & Lee, H. (2016). Sex, age, and the association of serum phosphorus with all-cause mortality in adults with normal kidney function. American journal of kidney diseases, 67(1), 79-88.
Koek, W. N. H., Campos-Obando, N., van der Eerden, B. C. J., De Rijke, Y. B., Ikram, M. A., Uitterlinden, A. G., ... &Zillikens, M. C. (2021). Age-dependent sex differences in calcium and phosphate homeostasis. Endocrine connections, 10(3), 273-282.
Sharma, J. K., Turner, M. E., Paynter, A. S., Norman, P. A., White, C. A., Ward, E. C., ... & Holden, R. M. (2024). Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle‐aged males. Andrology.
Rondanelli, M., Faliva, M. A., Tartara, A., Gasparri, C., Perna, S., Infantino, V., ... &Peroni, G. (2021). An update on magnesium and bone health. Biometals, 34(4), 715-736.
Zioła-Frankowska, A., Kubaszewski, Ł., Dąbrowski, M., Kowalski, A., Rogala, P., Strzyżewski, W., ... &Frankowski, M. (2015). The content of the 14 metals in cancellous and cortical bone of the hip joint affected by osteoarthritis. BioMed research international, 2015(1), 815648.
Kosik-Bogacka, D. I., Lanocha-Arendarczyk, N., Kot, K., Zietek, P., Karaczun, M., Prokopowicz, A., ... &Ciosek, Z. (2018). Calcium, magnesium, zinc and lead concentrations in the structures forming knee joint in patients with osteoarthritis. Journal of Trace Elements in Medicine and Biology, 50, 409-414.
Yasin, T., Khan, M., Iqbal, H., Azam, H., Sukhera, S., &Arif, H. A. (2024). Correlation of Vitamin D and Calcium Levels and their Biochemical Importance in Diabetic Patients.
Hernando, V. U., Andry, M. M., Virginia, P. F. M., &Valentina, A. (2020). Vitamin D nutritional status in the adult population in Colombia–An analytical cross-sectional study. Heliyon, 6(2).
Akimbekov, N. S., Digel, I., Sherelkhan, D. K., &Razzaque, M. S. (2022). Vitamin D and phosphate interactions in health and disease. In Phosphate Metabolism: From Physiology to Toxicity (pp. 37-46). Cham: Springer International Publishing.
Turner, M. E., Paynter, A. S., White, C. A., Mazzetti, T., Ward, E. C., Norman, P. A., ... & Holden, R. M. (2023). Sex differences in phosphate homeostasis: females excrete more phosphate and calcium after an oral phosphate challenge. The Journal of Clinical Endocrinology & Metabolism, 108(4), 909-919.
Peacock, M. (2021). Phosphate metabolism in health and disease. Calcified tissue international, 108, 3-15.
Matias, P., Ávila, G., Ferreira, A. C., Laranjinha, I., & Ferreira, A. (2023). Hypomagnesemia: a potential underlooked cause of persistent vitamin D deficiency in chronic kidney disease. Clinical Kidney Journal, 16(11), 1776-1785.
Malinowska, J., Małecka, M., &Ciepiela, O. (2020). Variations in magnesium concentration are associated with increased mortality: study in an unselected population of hospitalized patients. Nutrients, 12(6), 1836.
Li, D., Cai, Z., Pan, Z., Yang, Y., & Zhang, J. (2021). The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus. BMC Endocrine Disorders, 21, 1-15.
Uwitonze, A. M., &Razzaque, M. S. (2018). Role of magnesium in vitamin D activation and function. Journal of Osteopathic Medicine, 118(3), 181-189.
Rodríguez-Ortiz, M. E., Canalejo, A., Herencia, C., Martínez-Moreno, J. M., Peralta-Ramírez, A., Perez-Martinez, P., ... &Almaden, Y. (2014). Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration. Nephrology Dialysis Transplantation, 29(2), 282-289.
Shahsavani, Z., Asadi, A., Shamshirgardi, E., &Akbarzadeh, M. (2021). Vitamin D, magnesium and their interactions: A review. International Journal of Nutrition Sciences, 6(3), 113-118.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 د. مصطفى محمد دراه، رندى محمد محمد الصالحي، البشير محمد البشير يحمد، مختار عمر عقوب ، فاطمة ميلاد الزين ، خولة محمد عبد الرحمن عكاشة
This work is licensed under a Creative Commons Attribution 4.0 International License.
