Systematic meta-analysis on risk factors for Postoperative complica-tion in brain tumor surgery
Keywords:
Proximal humerus frac-ture, PHILOS plate, locking plate, internal fixation, shoulder outcomeAbstract
Background:
Brain tumor surgery represents a high-stakes and technically demanding area in neurosurgery. This study aims to systematically analyze the incidence and types of postoperative complications, using data from a tertiary care center, with emphasis on tumor type and surgical context.
Methods:
This meta-analysis is based on data collected between January 2022 and September 2023 from adult patients who underwent surgery for intracranial tumors. Adverse events (AEs) occurring within 30 days postoperatively were documented by attending neurosurgeons. Tumor histology, surgical approach, urgency, and complications were analyzed.
Results:
Among 1,173 patients (mean age 57.4 ± 15.3 years), 93.4% underwent elective surgery. The most common tumors were meningiomas (31.1%) and gliomas (28.2%). The rate of surgery-related AEs was 12.7%, with dural leaks observed in 1.5% of cases. Postoperative hemorrhage was a significant issue, especially among glioma patients; 10 experienced bleeding and 8 required reoperations. The 30-day mortality rate was 0.8%, with causes including postoperative bleeding (n=1), pulmonary embolism (n=2), and tumor progression (n=2).
Conclusions:
Despite the inherent risks associated with brain tumor surgery, the overall mortality in this cohort was low. Comprehensive documentation and early intervention strategies play a crucial role in improving patient outcomes following neurosurgical procedures.
References
. Bhat AR, Wani MA, Kirmani AR (2022) Infra-tentorial brain tumor subtypes in children and adults—surgical outcome in an ethnic population with a single regional tertiary center. Chin Neurosurg J 8(1):1–9
. Dao Trong P, Olivares A, El Damaty A, Unterberg A (2023) Adverse events in neurosurgery: a comprehensive single-center analysis of a prospectively compiled database. Acta Neurochir (Wien) 165(3):585–593
. Dasenbrock HH, Yan SC, Smith TR, Valdes PA, Gormley WB, Claus EB, Dunn IF (2017) Re-admission after craniotomy for tumor: a national surgical quality improvement program analy-sis. Neurosurgery 80(4):551–562
. De la Garza-Ramos R, Kerezoudis P, Tamargo RJ, Brem H, Huang J, Bydon M (2016) Surgical complications following malignant brain tumor surgery: an analysis of 2002–2011 data. Clin Neurol Neurosurg 140:6–10
. Delgado-Fernandez J, Garcia-Pallero MÁ, Blasco G, Penanes JR, Gil-Simoes R, Pulido P, Sola RG (2017) Usefulness of reintervention in recurrent glioblastoma: an indispensable weapon for increasing survival. World Neurosurg 108:610–617
. Dimick JB, Chen SL, Taheri PA, Henderson WG, Khuri SF, Campbell DA (2004) Hospital costs associated with surgical complications: a report from the private-sector National Surgical Quality Improvement Program. J Am Coll Surg 199(4):531–537
. Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213
. Donoho DA, Wen T, Babadjouni RM, Schwartzman W, Buchanan IA, Cen SY, Zada G, Mack WJ, Attenello FJ (2018) Predictors of 30- and 90-day readmission following craniotomy for malignant brain tumors: analysis of nationwide data. J Neurooncol 136(1):87–94
. Duclos A, Chollet F, Pascal L, Ormando H, Carty MJ, Polazzi S, Lifante J-C (2020) Effect of monitoring surgical outcomes using control charts to reduce major adverse events in patients: cluster randomised trial. BMJ 371:m3840
. Eisenring CV, Neidert MC, Bové DS, Held L, Sarnthein J, Krayenbühl N (2013) Re-duction of thromboembolic events in meningioma surgery: a cohort study of 724 consecutive patients. PLoS One 8(11):e79170
. Florman JE, Cushing D, Keller LA, Rughani AI (2017) A protocol for postoperative admission of elective craniotomy patients to a non-ICU or step-down setting. J Neurosurg 127(6):1392–1397
. Giesbrecht V, Au S (2016) Morbidity and mortality conferences: a narrative review of strategies to prioritize quality improvement. JT Comm J Qual Patient Saf 42(11):516–527
. Gómez Vecchio T, Corell A, Buvarp D, Rydén I, Smits A, Jakola AS (2021) Classifica-tion of adverse events following surgery in patients with diffuse lower-grade gliomas. Front Oncol 11
. Grundy PL, Weidmann C, Bernstein M (2008) Day-case neurosurgery for brain tu-mours: the early United Kingdom experience. Br J Neurosurg 22(3):360–367
. Houkin K, Baba T, Minamida Y, Nonaka T, Koyanagi I, Iiboshi S (2009) Quantitative analysis of adverse events in neurosurgery. Neurosurgery 65(3):587
. Houkin K, Baba T, Minamida Y, Nonaka T, Koyanagi I, Iiboshi S (2009) Quantitative analysis of adverse events in neurosurgery. Neurosurgery 65(3):587
. Ivanovic J, Seely AJE, Anstee C, Villeneuve PJ, Gilbert S, Maziak DE, Shamji FM, Forster AJ, Sundaresan RS (2014) Measuring surgical quality: comparison of postoperative ad-verse events with the American College of Surgeons NSQIP and the Thoracic Morbidity and Mortality classification system. J Am Coll Surg 218(5):1024–1031
. Jenkins FS, Vasella F, Padevit L, Mutschler V, Akeret K, Velz J, Regli L, Sarnthein J, Neidert MC (2021) Preoperative risk factors associated with new focal neurological deficit and other major adverse events in first-time intracranial meningioma neurosurgery. Acta Neurochir (Wien) 163(10):2871–2879
. Kashiwazaki D, Saito H, Uchino H, Akioka N, Hori E, Shibata T, Tomita T, Akai T, Kuwayama N, Kuroda S (2020) Morbidity and mortality conference can reduce avoidable morbidity in neurosurgery: its educational effect on residents and surgical safety outcomes. World Neurosurg 133:e348–e355
. LandrielIbañez FA, Hem S, Ajler P, Vecchi E, Ciraolo C, Baccanelli M, Tramontano R, Knezevich F, Carrizo A (2011) A new classification of complications in neurosurgery. World Neurosurg 75(5–6):709–715 (discussion 604-611)
. Lassen B, Helseth E, Rønning P, Scheie D, Johannesen TB, Mæhlen J, Langmoen IA, Meling TR (2011) Surgical mortality at 30 days and complications leading to recraniotomy in 2630 consecutive craniotomies for intracranial tumors. Neurosurgery 68(5):1259–1268 (dis-cussion 1268-1269)
. Lenga P, Trong PD, Papakonstantinou V, Kiening K, Unterberg AW, Ishak B (2023) Adverse events in spine surgery: a prospective analysis at a large tertiary center in Germany. Acta Neurochir (Wien). https://doi.org/10.1007/s00701-023-05752-x
. Lohmann S, Brix T, Varghese J, Warneke N, Schwake M, Molina ES, Holling M, Stummer W, Schipmann S (2020) Development and validation of prediction scores for noso-comial infections, reoperations, and adverse events in the daily clinical setting of neurosurgical patients with cerebral and spinal tumors. J Neurosurg 134(4):1226–1236
. Lonjaret L, Guyonnet M, Berard E et al (2017) Postoperative complications after crani-otomy for brain tumor surgery. Anaesth Crit Care Pain Med 36(4):213–218
. Meyer HS, Wagner A, Obermueller T, Negwer C, Wostrack M, Krieg S, Gempt J, Mey-er B (2022) Assessment of the incidence and nature of adverse events and their association with human error in neurosurgery. A prospective observation. Brain Spine 2:100853
. Neumann J-O, Schmidt S, Nohman A, Jakobs M, Unterberg A (2023) Routine ICU admission after brain tumor surgery: retrospective validation and critical appraisal of two pre-diction scores. Acta Neurochir (Wien) 165(6):1655–1664
. Nuño M, Ly D, Ortega A, Sarmiento JM, Mukherjee D, Black KL, Patil CG (2014) Does 30-day readmission affect long-term outcome among glioblastoma patients? Neurosur-gery 74(2):196–204 (discussion 204-205)
. Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, Barnholtz-Sloan JS (2019) CBTRUS statistical report: primary brain and other central nervous system tumors diag-nosed in the United States in 2012–2016. Neuro-Oncol 21(Suppl 5):v1–v100
. Schipmann S, Brix T, Varghese J, Warneke N, Schwake M, Brokinkel B, Ewelt C, Du-gas M, Stummer W (2019) Adverse events in brain tumor surgery: incidence, type, and impact on current quality metrics. Acta Neurochir (Wien) 161(2):287–306
. Senders JT, Muskens IS, Cote DJ, Goldhaber NH, Dawood HY, Gormley WB, Broek-man MLD, Smith TR (2018) Thirty-day outcomes after craniotomy for primary malignant brain tumors: a national surgical quality improvement program analysis. Neurosurgery 83(6):1249–1259
. Tanaka S, Meyer FB, Buckner JC, Uhm JH, Yan ES, Parney IF (2013) Presentation, management, and outcome of newly diagnosed glioblastoma in elderly patients. J Neurosurg 118(4):786–798
. Terrapon APR, Zattra CM, Voglis S et al (2021) Adverse events in neurosurgery: the novel Therapy-Disability-Neurology grade. Neurosurgery 89(2):236–245
. Vasella F, Velz J, Neidert MC, Henzi S, Sarnthein J, Krayenbühl N, Bozinov O, Regli L, Stienen MN (2019) Safety of resident training in the microsurgical resection of intracranial tumors: data from a prospective registry of complications and outcome. Sci Rep 9(1):954
. Wanis HA, Møller H, Ashkan K, Davies EA (2021) The incidence of major subtypes of primary brain tumors in adults in England 1995–2017. Neuro-Oncol 23(8):1371–1382
. Xue H, Sveinsson O, Bartek J, Förander P, Skyrman S, Kihlström L, Shafiei R, Mathiesen T, Tomson T (2018) Long-term control and predictors of seizures in intracranial meningioma surgery: a population-based study. Acta Neurochir (Wien) 160(3):589–596
. Zegers M, de Bruijne MC, de Keizer B, Merten H, Groenewegen PP, van der Wal G, Wagner C (2011) The incidence, root-causes, and outcomes of adverse events in surgical units: implication for potential prevention strategies. Patient Saf Surg 5:13
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Amina mohammed khdora، Eman mahmod kram mahammed، Ahmed Omar Abushahma

This work is licensed under a Creative Commons Attribution 4.0 International License.