The effect of ethanolic extract and Caffeine extract of the yerba Meta plant (ilex paraguariensis) on the vital functions and tissues of the liver and kidneys in guinea pigs
الملخص
The active compounds contained in medicinal plants are generally the ones to which the therapeutic effect of diseases is attributed. This study aims to use the caffeine alkaloid extracted from the plant and the ethanolic extract of the yerba mate plant to know its effect on blood contents and rates of fat and vital tissues using experimental animals of the guinea pig type males, which are divided into five groups equally. The fifth group is a control group, and the first and second groups were injected with caffeine at a concentration of 10 and 20 mg/kg, respectively, and the third group was injected with yerba mate at a concentration of 200 mg/kg, while the fourth group was injected with mate at a concentration of 100 mg/kg. At the end of the experiment, blood samples were taken to examine lipid levels and blood biometrics, and organs (kidneys, liver) were removed. Transfer it to the laboratory to conduct histological examinations. It was concluded from these tests that the extract of ethanol from the Yerba mate plant at a concentration of 200 mg/kg reduces the level of cholesterol and triglycerides in the blood. It is estimated with statistical significance (P = 0.0035).
المراجع
Anyanwu, s., Inyang, IJ., Asemota, EA, Obioma, OO, Okpokam, DC., Agu, VO. (2017) Effect of ethanolic extract of Chromolaena odorata on the kidneys and intestines of healthy albino rats. Integr Med Res. 6(3): 292-299. doi: 10.1016Lj.imr.2017.06.004.Epub2017 Jul 8. PMID:28951843; PMCID: PMC5605375.
Bastos, J., Lunet, N., & Azevedo, A. (2005). Caffeine and abortion risk: a systematic review and meta-analysis. European Journal of Epidemiology, 20(5), 385-394.
Borges-Piovezan, M., et al. (2015). Antioxidant Effect of Ilex paraguariensis Extracts in the Central Nervous System of Rats. Oxidative Medicine and Cellular Longevity, 2015.
Bravi F, Bosetti C, Tavani A, Gallus S, La Vecchia C. Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis. Clin Gastroenterol Hepatol. 2013 Nov;11(11):1413-1421.e1. doi: 10.1016/j.cgh.2013.04.039. Epub 2013 May 6. PMID: 23660416.
Burris, K., Ashida, C., & Albala-Bertrand, M. (2012). The Health Benefits of Mate Tea: A Review of the Evidence. Journal of Food Science and Technology, 49(4), 400-412.
Costa J, Lunet N, Santos C, Santos J, Vaz-Carneiro A. Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies. J Alzheimers Dis. 2010;20 Suppl 1:S221-S238. doi:10.3233/JAD-2010-091525
Dallago et al. (2011). Chemical Composition and Antioxidant Activity of Yerba-Mate (Ilex paraguariensis A.St.-Hil., Aquifoliaceae) Extract as Obtained by Spray Drying Technique. Journal of Agricultural and Food Chemistry, 59(10), 5523-5527.
Eskelinen MH, Kivipelto M. Caffeine as a protective factor in dementia and Alzheimer's disease J Alzheimers Dis. 2010;20 Suppl 1:S167-S174. doi:10.3233/JAD-2010-1404
Freedman ND, Curto TM, Lindsay KL, Wright EC, Sinha R, Everhart JE; HALT-C TRIAL GROUP Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C. Gastroenterology. 2011 Jun;140(7):1961-9. doi: 10.1053/j.gastro.2011.02.061. Epub 2011 Mar 2. PMID: 21376050; PMCID: PMC3109110.
Heck, C. I., & Mejia, E. G. (2007). Yerba Mate Tea (Ilex paraguariensis): A Comprehensive Review on Chemistry, Health Implications, and Technological Considerations. Journal of Food Science, 72(9), R138-R151.
Jarrar, A., Salim, A., Alahmed, T. Principles of practical organic chemistry. Dar Alddia. 1999. PP: 150.
Liu F, Wang X, Wu G, Chen L, Hu P, Ren H, Hu H. Coffee Consumption Decreases Risks for Hepatic Fibrosis and Cirrhosis: A Meta-Analysis. PLoS One. 2015 Nov 10;10(11):e0142457. doi: 10.1371/journal.pone.0142457. PMID: 26556483; PMCID: PMC4640566.
Loftfield E, Freedman ND, Graubard BI, Guertin KA, Black A, Huang WY, Shebl FM, Mayne ST, Sinha R. Association of coffee consumption with overall and cause-specific mortality in a large US prospective cohort study [published correction appears in Am J Epidemiol. 2015 Mar 15;181(6):431]. Am J Epidemiol. 2015;182(12):1010-1022.
Mejia, D., & Heck, C. I. (2007). Yerba Mate Tea: A Comprehensive Review on Chemistry, Health Implications, and Technological Considerations. Food Research International, 40(10), 1245-1257.
Nehlig, A., Daval, J. L., & Debry, G. (1992). Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain research reviews, 17(2), 139-170.
Popat RA, Van Den Eeden SK, Tanner CM et al.. Coffee, ADORA2A polymorphisms and Parkinson's disease risk [published correction appears in Mov Disord Clin Pract (Hoboken). 2020 Jan-Feb;7(1):107]. Mov Disord Clin Pract (Hoboken). 2020;7(1):92-99.
Shimoda, H., et al. (2006). Antioxidative activity of green tea extracts in vitro and their inhibitory effect on lipid oxidation of pork meat patties. Journal of the Science of Food and Agriculture, 86(10), 1451-1456.
Valle-Martos R, Valle M, Martos R, Cañete R, Jiménez-Reina L, Cañete MD. Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity. Front Pediatr. 2021 Feb 16;9:629346. doi: 10.3389/fped.2021.629346. PMID: 33665176; PMCID: PMC7921725.
van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review [published correction appears in JAMA 2006 Nov 22;296(20):2468]. JAMA. 2005;294(1):97-104.
Wendling et al. (2016). Effects of Chronic Administration of Mate Tea (Ilex paraguariensis) on Gene Expression Related to Energy Metabolism in Rat Liver: A High-Fat Diet Study. Journal of Functional Foods, 23(C), 1-11.
Zheng, W., et al. (2004). Antioxidant activity and phenolic compounds in selected herbs. Journal of Agricultural and Food Chemistry, 52(16), 4950-4954.
Gao Y, et al. Protective effects of yerba mate extract against oxidative DNA damage in liver, kidney, and bladder cells in mice. J Med Food. 2014;17(6):657-664. doi:10.1089/jmf.2013.0127
de Andrade F, et al. Antioxidant properties of yerba mate (Ilex paraguariensis) on oxidative stress induced by ultraviolet C radiation in the skin of hairless mice. J Photochem Photobiol B Biol. 2009;95(3):167-173. doi:10.1016/j.jphotobiol.2009.04.001
Pimentel GD, et al. Effects of yerba mate supplementation on liver metabolism, lipogenesis, antioxidant defenses and serum adipokines in rats fed a high-fat diet. Food Chem Toxicol. 2012;50(10):3781-3787.doi:10.1016/j.fct.2012.
التنزيلات
منشور
كيفية الاقتباس
إصدار
القسم
الرخصة
الحقوق الفكرية (c) 2024 Raja Aburwais ، Emhemed Abukhattala، Fadi Ashini، Monder Arafat
هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.