A study of phytochemical screening and anticonvulsant activities of Phoenix dactylifera L. leaflets in animal models
الملخص
The Phoenix dactylifera L (date palm) belonging to family Arecaceae, called 'Nakhl' is endowed with various medicinal properties; however, utilization of leaf as a source of drugs has not yet been explored. The aims of the present study were to evaluate its anticonvulsant effects using PTZ and INH-induced seizures models. The fresh and dried leaflets of Taboni and El-Ammi cultivars were extracted in aqueous, ethanol and methanol. Phytochemical screening of extracts revealed the presence of alkaloids, flavonoids, saponins, steroids and other bioactive compounds.
Anticonvulsant activity of palm leaf methanolic extract PLME, Taboni cultivar (100, 200, 400 mg/kg ip) once daily for five successive days was evaluated against PTZ (100mg/kg, i.p.)-induced convulsions in rats (n=6). Diazepam was used as standard drug. Behavioral response of the animal to PTZ administration were evaluated using these criteria: onset of clonic convulsion, incidence, mortality and, protection percent. Intraperitoneal administration of PLME surprisingly caused 100% protection against clonic-tonic convulsion and mortality induced by PTZ, while, acute administration of PLME (200 mg/kg) in a single dose produced significant(P< 0.0001) increase in generalized clonic-tonic seizure latency, the percent delay of convulsion was 75%, and produced complete protection against mortality following PTZ administration.
On the other hand intraperitoneal administration of PLAE, and PLEE, El-Ammi cultivar of PD, in different doses in a single or five successive days significantly (P< 0.0001) delayed the onset of convulsions against PTZ (80 mg/kg) and INH (300mg/kg)-induced seizures in mice respectively. Despite that both extracts did not completely protect the mice against clonic-tonic convulsions and mortality. The anticonvulsant activity of date palm leaflets extracts may be due to GABA-ergic stimulation.
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التنزيلات
منشور
كيفية الاقتباس
إصدار
القسم
الرخصة
الحقوق الفكرية (c) 2018 Hussein Abubaker Diab1، Amna El-Hadi. Kridish1، Ahlam , Mohamed El-Ahmer1 ، Samar Ibrahim El-Gasri1، Nawal Omar Abaurawi1، Naisreen Ali El- Karshin1، Zuhra Ali Tiabin2، Sara Muftah Wqah2، Aisha Agil Elginidi2، Nawara Omar abaurawi
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