The prevalence and health consequences of consanguineous marriage in Misurata city-Libya

Aiman Krayem; sahar abusin

المؤلفون

Aiman Krayem libyan academy
sahar abusin Misrata medical center Department of pediatrics & neonatology

الكلمات المفتاحية:

Consanguineous، marriage، congenital، coefficient of inbreeding، Misurata

الملخص

Background: consanguinity is defined as a union between second cousins or closer with an inbreeding coefficient greater than or equal to 0.0156. Consanguinity is practiced by up to 10% of the global population, with rates ranging from 80.6% in certain Middle Eastern provinces to less than 1% in Western societies.

METHODS: A cross-sectional study was conducted in MISRATA CITY – LIBYA between January 2024 and January 2025 to determine the impact of consanguineous marriages on offspring health.

Filling prepared questionnaire (copy attached) with direct interviewing of random sample of parents attending Misurata Medical Centre for any reasons. Ethical considerations: formed consent from one of the parents and consent from the ethical committee at Misurata Medical Centre

Results: In our study, parental consanguinity was associated with a higher likelihood of consanguineous unions. the education level between the wives varying between elementary (25%), high school (18%), bachelor (30%) while on the other hand for the husbands the education level were, elementary (33%), diploma & technical institution (34%), bachelor (20%) which reflect the focusing skilled education for the males. Women marriage before age 23 was significantly higher than that of their late marrying counterparts. On the other hand, men have a significantly higher likelihood (1.99 times) of contracting consanguineous unions between the ages of 23 and 29.

المراجع

Bittles ah. Consanguinity and its relevance to clinical genetics. Clin genet. 2001;60(2):89–98. Https://doi.org/10.1034/j.1399-0004.2001.600201.x

Oniya o, neves k, ahmed b, konje jc. A review of the reproductive consequences of consanguinity. Eur j obstet gynecol reprod biol. 2019;232:87–90. Https://doi.org/10.1016/j.ejogrb.2018.10.042

Bittles ah, black ml. Consanguinity, human evolution, and complex diseases. Proc natl acad sci usa. 2010;107(suppl 1):1779–86.

Hamamy h, jamhawi l, al-darawsheh j, ajlouni k. Consanguineous marriages in jordan: why is the rate changing with time? Clin genet. 2005;67(6):511–6. Https://doi.org/10.1111/j.1399-0004.2005.00426.x

Bener a, mohammad rr. Global distribution of consanguinity and their impact on complex diseases: genetic disorders from an endogamous population. Egypt j med hum genet. 2017;18(4):315–20. Https://doi.org/10.1016/j.ejmhg.2017.01.002

Varela ta, lodeiro r, farina j, pena ja, calo mc, vona g. Etude de la consanguinité et de ses effets. In: suzanne c, rebato e, chiarelli b, editors. Anthropologie biologique: évolution et biologie humaine. Bruxelles: de boeck; 2003. P. 381–93.

Bittles ah, hamamy ha. Endogamy and consanguineous marriage in arab populations. In: teebi a, editor. Genetic disorders among arab populations. Heidelberg: springer; 2010. P. 85–108.

Talbi j, khadmaoui a, soulaymani a, chafik a. Etude de la consanguinité dans la population marocaine. Impact sur le profil de la santé. Antropo. 2007;15:1–11.

Alvarez g, quinteiro c, ceballos fc. Inbreeding and genetic disorder. In: ikehara k, editor. Advances in the study of genetic disorders. Rijeka: intech; 2011. P. 21–44.

Benmakhlouf y, zian z, ben makhlouf k, ghailani nourouti n, barakat a, bennani mm. Intellectual disability in morocco: a pilot study. Innov clin neurosci. 2020;17:9–13.

Anwar s, taslemmourosi j, arafat y, hosen mj. Genetic and reproductive consequences of consanguineous marriage in bangladesh. Plos one. 2020;15(11):e0241610. Https://doi.org/10.1371/journal.pone.0241610

Goundali ke, bouab c, rifqi l, chebabe m, hilali a. Les mariages consanguins et leurs effets sur les maladies non transmissibles dans la population marocaine: étude transversale. Pan afr med j. 2022;41:221. Https://doi.org/10.11604/pamj.2022.41.221.31273

Romdhane l, mezzi n, hamdi y, el-kamah g, barakat a, abdelhak s. Consanguinity and inbreeding in health and disease in north african populations. Annu rev genomics hum genet. 2019;20:155–79. Https://doi.org/10.1146/annurev-genom-083118-014954

Barbouche mr, mekki n, ben-ali m, ben-mustapha i. Lessons from genetic studies of primary immunodeficiencies in a highly consanguineous population. Front immunol. 2017;8:737. Https://doi.org/10.3389/fimmu.2017.00737

Islam mm. Effects of consanguineous marriage on reproductive behaviour, adverse pregnancy outcomes, and offspring mortality in oman. Ann hum biol. 2013;40(3):243–55. Https://doi.org/10.3109/03014460.2012.761885

Cheffi k, dahbi n, el khair a, stambouli h, elbouri a, talbi j, et al. Consanguinity in the chaouia population (morocco): prevalence, trends, determinants, fertility, and spontaneous abortions. Egypt j med hum genet. 2022;23:27. Https://doi.org/10.1186/s43042-022-00313-w

Montagne r. Les berbères et le makhzen dans le sud du maroc. Paris: félix alcan; 1930.

Direction régionale de guelmim oued-noun. Monographie provinciale: province de sidi ifni. Guelmim: drgon; 2020.

Direction régionale de souss massa. Monographie sur le secteur de l’habitat et de la politique de la ville de la région souss massa. Agadir: drsm; 2019.

Badri l. La décentralisation au maroc: quelles perspectives pour la gouvernance locale et le développement territorial? (cas de la régionalisation avancée) [dissertation]. Grenoble: grenoble alpes university; 2019.

Handaine m. Tamdoult, histoire d’un carrefour de la civilisation maroco-touarégue. Rabat: bouregreg; 2008.

El hamel c. ‘race’, slavery and islam in maghribi mediterranean thought: the question of the haratin in morocco. J n afr stud. 2002;7(1):29–52. Https://doi.org/10.1080/13629380208718472