Fentanyl and Propofol Used at The Conclusion of Anesthesia in Pediatrics Patients to Reduce Emerging Anxiety Following Sevoflurane Anesthesia:  A Comparative Study in Libyan Patients

Ibrahim Garta; Omar Alhaddad; Abdulrahman eldanfour; FATHI ABULIFA; Ahmed Aniba

المؤلفون

Ibrahim Garta جامعة مصراتة -كلية الطب البشري
Omar Alhaddad Department of Family and Community Medicine, Faculty of Medicine Misurata University Libya
Abdulrahman eldanfour Anesthesia Department Misurata central hospital Libya
FATHI ABULIFA Department of Surgery, Faculty of medicine, Misurata University, Libya
Ahmed Aniba Department of Surgery, Faculty of medicine, Misurata University Libya

الكلمات المفتاحية:

Anaesthetics، propofol، sevoflurane، fentanyl، Misurata

الملخص

Background: The optimal drug for reducing emergence agitation (EA) after sevoflurane anesthesia remains unclear, with both propofol and fentanyl as potential options.

Aim: This study aimed to compare the effects of fentanyl and propofol on the incidence and severity of postoperative agitation and excitement following sevoflurane anesthesia.

Methods: Sixty-six children who underwent sevoflurane anesthesia were prospectively assigned to three groups. Group P received propofol 1 mg/kg, Group F received fentanyl 1 μg/kg, and Group S received saline. EA was assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale, alongside recovery time and the occurrence of nausea and vomiting.

Results: Group P and Group F had mean PAED scores of 5.05 and 5.2, respectively (p=0.715), significantly lower than Group S (14, p<0.001). Group F had a significantly higher frequency of nausea and vomiting compared to Group P (p<0.001), while differences between Groups P and S were not clinically significant. Group P had a shorter stay in the post-anesthesia care unit (PACU) than Group F (p=0.06), though this difference was not clinically significant. However, Group F had a significantly longer PACU stay than Group S (p=0.01).

Conclusion: Both propofol and fentanyl reduced the incidence of EA after sevoflurane anesthesia, but propofol was associated with a lower rate of nausea and vomiting, making it the preferable option.

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